We are interested in how molecules, macromolecules, vesicles, and both biological and synthetic elements can be combined to create life-like behaviours and bio-inspired biotechnologies. Our work focuses on designing and constructing synthetic cells, minimal systems built from the bottom up using biomolecules and synthetic components. These systems offer unprecedented potential to unravel fundamental biological principles and pave the way for novel applications. Using a bottom-up approach, we mimic biological complexity through design concepts – combining principles of soft matter, physical chemistry, and biochemistry, we bridge physical sciences, engineering, and biomedical sciences to translate this knowledge into innovative nanomedicines and bio-inspired technologies.

Soft Matter Engineering

We design lipid, polymer, and hybrid vesicles that serve as minimal models of cellular membranes. By controlling membrane composition, architecture, and mechanical properties, we investigate how soft matter systems can mimic biological structures and functions.

Membrane Biophysics

Our research investigates the fundamental physical principles governing membrane organisation, nanoparticle–membrane interactions, and transport across biological interfaces. Minimal membrane systems allow us to isolate the mechanisms that drive cellular behaviour.

Cell-like Dynamic Behaviour

Living cells display complex behaviours such as motion, deformation, and responsiveness to environmental cues. We engineer synthetic systems capable of life-like dynamics, including contractility, self-organisation, and autonomous motion.

Biohybrid Systems

We combine synthetic materials with living cells to create biohybrid systems with enhanced functionality. These platforms enable new strategies for cellular engineering, biosensing, and therapeutic delivery.